The A713 is currently closed between Queen Margaret and Ayr Hospital main entrance due to flooding on the road just before Queen Margaret, Local diversions are in place via the A77 and Dalrymple.
Several broken down cars are also blocking the A713 just before Ayr Hospital.
In a statement from Ayrshire Police Division on Social Media, they said: "The heavy rain throughout the day has caused poor driving conditions across Ayrshire tonight. Many roads are affected by heavy flooding in places. Drivers should slow down and drive to the conditions.
"The heavy rain is expected to continue until the morning."
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