Police received a report of a two-vehicle crash, involving a car and a van, on the A70 westbound near Ayr around 5.55am on Friday, 28 October, 2022.
Emergency services attended, however a 46 year-old woman, the driver of the van, was pronounced dead at the scene.
The male driver of the car was taken by ambulance to Queen Elizabeth University Hospital in Glasgow and the female passenger of the van was taken to Crosshouse Hospital.
The road has now reopened following full collision investigation work.
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